The 9 best longevity and anti-aging compounds

In the eternal quest for the fountain of youth, humanity has long sought ways to counter the inevitable effects of aging. The marks of time don't just affect our appearance; they lead to a cascade of physical and mental changes that can significantly impact our overall well-being and zest for life. But what if the hands of time don't have to hold you tight? That you could, to some extent, influence the aging process?

Enter the world of longevity and anti-aging supplements, a promising frontier in the fight against the visual and physiological toll of getting older. Though topical treatments like anti-aging creams have their place, recent scientific discoveries indicate that the real key to unlocking youth may lie at the cellular level. By targeting aging from the inside, we may be able to rejuvenate not only our skin's vibrant appearance but also foster a youthful vigor that resonates throughout our entire being.

This intriguing prospect has led to a surge in popularity for this class of supplements, but a sea of options can quickly become overwhelming. With countless products claiming miraculous benefits—some touting outdated or dubious scientific support—how can one navigate this complex landscape?

Fear not, for we've carefully sifted through the noise to present you with the nine most potent compounds, each backed by robust clinical and scientific evidence. These gems of longevity hold the promise of not just slowing down aging but actively promoting a healthier, more youthful existence. Join us as we explore these scientifically-endorsed elixirs of life, guiding you towards an informed and confident choice in your pursuit of timeless vitality.

1. Nicotinamide mononucleotide (NMN)

NMN is a molecule involved in the production of nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for DNA repair and other vital processes in the body. Research has shown that NMN supplementation can increase lifespan in mice by up to 29% and reverse various aspects of aging in humans and other model organisms. In addition, NMN has also been found to reduce oxidative stress and inflammation, increase skin moisture and improve skin barrier function. This suggests that NMN can protect the skin from premature aging and environmental damage. [1][2]

2. Alpha-ketoglutarate (AKG)

Alpha-ketoglutarate is a compound used as a fuel by the mitochondria, the power plants of our cells. It plays an essential role in maintaining bone strength and proper digestive function and has been shown to improve skin health and appearance by impacting collagen production. Besides reducing skin aging, AKG may even have the potential to slow down and reverse hair greying, increase lifespan and reduce frailty, based on studies in various model organisms. While the exact mechanism of action is still unknown, researchers believe the effects are mainly due to AKG's anti-inflammatory properties. Supplementation with AKG has been shown to reduce low-grade inflammation (LGI) by up to 80% in humans. LGI is associated with numerous health problems and drastically accelerates aging in all parts of the body, including the skin. Most notably, a 2021 clinical trial showed that AKG supplementation decreased biological aging in humans by an average of 8 years based on DNA methylation testing, making it one of the most potent longevity interventions available. [3][4][5][6][7]

3. D-Glucosamine

Glucosamine is a compound produced by the body and involved in the formation and repair of tissues, including the skin. Supplementation with D-glucosamine has been shown to increase collagen levels, leading to a reduction in wrinkles and improving skin health. It has also been shown to have anti-inflammatory and antioxidant effects, which may help to protect against oxidative stress and the associated aging process. Furthermore, D-glucosamine has been found to improve joint health in people with osteoarthritis on par with the effectiveness of conventional medications and treatments. [8][9][10][11][12]


4. Betaine (TMG)

Betaine, also known as trimethylglycine (TMG), is another naturally present compound in the body. It is involved in the methylation process, which is essential for proper cell function. TMG has several health benefits, including reducing inflammation, improving liver function, supporting cardiovascular health, and improving skin health. It also has strong evidence indicating its ability to protect against certain types of cancer. In addition, it extends the life span of mice by up to 6 percent, as shown by the interventions testing program. Finally, there is convincing mechanistic evidence that TMG and NMN may have a synergistic effect, further increasing their effectiveness. [13]

5. Spermidine

Spermidine is another compound that has gained attention recently due to its potential to promote healthy aging. A peer-reviewed study published in Nature found that spermidine supplementation extends the mean lifespan of multiple model organisms by up to 30%. Spermidine supplementation mimics the effects of caloric restriction or intermittent fasting, a powerful longevity-promoting practice. Spermidine does so by inducing autophagy, a process by which cells recycle and repair themselves. Furthermore, spermidine supplementation has the potential to improve skin health. A recent study published in Nature Communications found that it improved the dermal structure and skin barrier function. While the body naturally produces spermidine, it is also present in small amounts in foods such as whole grains, legumes, nuts, and fermented foods like natto (fermented soybeans). [14][15]

6. Lithium

Lithium is a trace element that is essential for the proper functioning of the body's cells. It has several health effects, including the ability to extend lifespan and increase health span in humans and other animals. For instance, a study published in Cell shows that supplementation of low-dose lithium significantly extends the lifespan of Drosophila fruit flies, while another study found that it increased lifespan by up to 46% in C. elegans, two commonly used model organisms in longevity research. In humans, lithium is used in high doses as a first-line treatment for mood stabilization in the treatment of depression. However, studies show that even very low microdoses of lithium may support overall health and wellness in healthy individuals as well. For example, regions with higher doses of lithium in their drinking water have been found to have lower rates of suicide and crime, as well as increased happiness. Additionally, lithium may also have the potential to protect against certain types of dementia and improve cognitive function. [16][17][18][19]

7. Fisetin

Fisetin is a flavonoid compound found in various fruits and vegetables such as strawberries, apples and cucumbers. It has many beneficial effects on the body, including extending lifespan and increasing health span across multiple model organisms. One of the key mechanisms by which fisetin supports healthy aging is by reducing the number of senescent cells in the body, making it a so-called senolytic. Senescent cells are cells that have stopped dividing and begin to accumulate in our bodies over time. These cells then accelerate aging by secreting inflammatory molecules and damaging healthy surrounding cells. As senescent cells accumulate in all major compartments of our bodies, including the skin, they drive some of the typical visual signs of skin aging, such as wrinkles and decreased elasticity. By reducing the number of senescent cells in the skin and beyond, fisetin can help slow down aging and promote a healthy, youthful appearance. In addition to reducing the visible effects of aging, fisetin has cognitive-enhancing effects. A study in mice found that those supplemented with fisetin performed significantly better on cognitive tests and had a 30% increase in long-term memory compared to the control group, making fisetin one of the most promising longevity compounds available. [20][21]

8. Quercetin

Another powerful senolytic agent is quercetin. Like fisetin, it is also a flavonoid found in various fruits and vegetables with numerous health and longevity-promoting properties. Although both senolytics target senescent cells, studies indicate that they do so via different mechanisms, which means that a combination of both likely leads to even greater health benefits. In addition to its senolytic function, Quercetin has anti-inflammatory and antioxidant properties, which protect cells from oxidative stress, a leading cause of accelerated aging. Furthermore, numerous studies have shown that quercetin reduces the risk of developing certain types of cancer and improves cognitive function. Like fisetin, quercetin also supports skin health by increasing the hydration and elasticity of the skin and reducing wrinkles in individuals with photoaged skin. [22][23]

9. Curcumin

Finishing up our list is another senolytic. Curcumin is a compound found in turmeric, a spice commonly used in Indian and Middle Eastern cuisine. It has compelling evidence showing health-promoting effects, including its ability to extend life span and increase health span. It may also potentially protect against certain types of cancer and improve cognitive function. Human clinical trials also found that curcumin can significantly improve vascular endothelial function and reduce oxidative stress, which may reduce the risk of stroke, heart attack, and other cardiovascular diseases. In addition, curcumin increases brain levels of BDNF, a protein that plays a crucial role in brain function and the development of new neurons. This makes it a neuroprotective compound that may aid in the prevention and treatment of Alzheimer's disease. Lastly, curcumin has been shown to have the potential to help in the treatment of depression, making it a promising natural alternative to traditional antidepressants and an overall highly beneficial supplement. [24][25][26][27]


In conclusion, the search for effective anti-aging and longevity supplements can be a daunting task with so many options on the market. However, by focusing on the compounds with the most robust clinical and scientific evidence, we can take steps toward supporting healthy aging and slowing down the visual and physiological effects of getting older. Our longevity supplement KEEY contains the nine ingredients mentioned, including NMN, AKG, D-glucosamine, betaine, and more. This is no coincidence. Our team of leading longevity researchers and data scientists utilizes AI technology to carefully analyze thousands of studies on longevity and identify the most promising interventions. Our formula is constantly updated with the latest research to ensure you receive the best quality supplement possible. By addressing all 9 Hallmarks of aging directly, KEEY can help you function and feel younger for longer.

Disclaimer: This article has been written and provided by Extesia, the company behind the KEEY longevity supplement mentioned within. Always consult with a healthcare professional before starting any new supplement.

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